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Figure 4 Results of measurement of matrix metalloproteinase (MMP)-2 protein (A) and messenger ribonucleic acid (mRNA) (B) in left ventricular (LV) extracts of Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats at the left ventricular hypertrophy (LVH) and congestive heart failure (CHF) stages. The MMP-2 proteins and mRNA were measured by Western and Northern blot analyses, respectively. The MMP-2 mRNA level was normalized to that of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA. The data are expressed as arbitrary units (values for 11-week-old DR rats were set at 1.0, and remaining values were adjusted accordingly) and mean values ± SEM. *p < 0.01; p < 0.05. (A) p_a = 0.0044, p_t = 0.0016 and p_i = 0.0026. (B) p_a < 0.001, p_t < 0.001 and p_i = 0.0017. W = weeks.

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