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Figure 5 (A, top row) The action potential duration restitution (APDR) curves. (B, bottom row) Corresponding nonlinear slopes plotted as a function of DI obtained at four sites of the right atrium (high lateral [HL], high septal [HS], mid posterior [MP] and mid lateral [ML]). Shortening of action potential duration at 90% repolarization (APD90) with decreasing diastolic interval (DI) in patients with chronic atrial fibrillation (CAF) (left panels) was greater at the HL and ML sites than at the MP and HS sites, resulting in a change in the maximal slope (Slopemax) of 2.1. In patients with paroxysmal atrial fibrillation (PAF) (middle panels),  Slopemax was 1.7. Regional differences of the APDR curve were not evident in the control subjects (right panels), and resulted in a Slopemax of 0.8.
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