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Figure 4 Lamin A/C immunostain (a, c, e) and corresponding DAPI nuclear stain (b, d, f). (a, b) Normal heart sample. (c, d) Control dilated cardiomyopathy without (LMNA) mutation; all myocyte and interstitial-vascular nuclei are immunostained by the anti-LMNA antibody. (e, f) Endomyocardial biopsy from patient A-II-1; note the absence of LMNA immunostain in some myocyte nuclei and positive interstitial-vascular cell nuclei (Avidin-Biotin Complex, DAPI nuclear stain; a and b, 40x; c to f, 110x).
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