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Figure 3 Effects of dichloroacetate (DCA) on the recovery of cardiac work, cardiac efficiency and pHi of hearts reperfused after ischemia. Values are mean ± SEM of eight glucose+palmitate perfused hearts (closed circles) and eight glucose+palmitate + DCA perfused hearts (closed triangles). Isolated working hearts were subjected to 20 min of global no-flow ischemia and 40 min of aerobic reperfusion. DCA (3 mmol/l) was added immediately before reperfusion. *Significant time-treatment interaction as determined by two-way analysis of variance with repeated measures on time. After application of the Huyhn-Feldt correction, p-values for the time-treatment interaction for cardiac work, cardiac efficiency and pHi are 0.004, 0.008 and <0.0001, respectively.
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