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Figure 2 To analyze the correlation between the development of intimal thickening and ET-1 ligand and receptor expression, allograft recipients were given CsA at a dose of either 1.0, 1.5 or 2 mg/kg per day for two weeks, followed by one week of CsA at 1 mg/kg per day. The correlation of intimal thickening with ET-1 (left column), ETA (middle column) and ETB (right column) protein expression in the arterial wall of chronically rejecting allografts, analyzed by linear regeression analysis. Correlation coefficients (r2) are given. Immunohistochemistry findings were scored from 0 to 3 (0 = no visible staining; 1 = few cells with faint staining; 2 = moderate intensity with multifocal staining; and 3 = intense diffuse staining of the cells).
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