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Figure 2 Immunoblot analysis of cytochrome c and manganese superoxide dismutase (MnSOD; as a marker of the mitochondrial matrix) in the cytosol (a) and total cell lysate (b) of left ventricular specimens from donor hearts and failing hearts. In the failing myocardium, cytosolic cytochrome c was 53% higher (c), whereas MnSOD was not different between the two groups in terms of the cytosolic fraction and total lysate. In cultured rat cardiomyocytes, cytochrome c release could only be detected after treatment with 10 µmol/l of norepinephrine for 24 h (d). *p < 0.05.
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