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Figure 5 (A) Isoproterenol-stimulated adenylate cyclase activity in the failing myocardium, with or without cardiac support device (CSD) treatment. The CSD resulted in an enhanced dose response to isoproterenol. The p value is for the CSD effect on the dose response, by two-way analysis of variance. (B) Adenylyl cyclase activity with direct activation by forskolin revealed no difference between the groups, suggesting altered up-stream signaling as the major source for the disparity in part A. CHF = chronic heart failure.
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