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Figure 5 Quantitation of ventricular mechanical dyssynchrony. (A) Spatial dyssynchrony; a coefficient of variation of regional fractional area change (RFAC) measured at the time of maximal negative RFAC; (B) temporal dyssynchrony; a coefficient of variation of time at maximal negative RFAC; left ventricular (LV) or biventricular (BiV) pacing significantly improved both measures in nearly all patients. (C) Improvement in EF induced by LV or BiV pacing. (D) There was a negative correlation between the extent of spatial dyssynchrony and systolic function, and most all subjects showed a shift upward and to the left with active pacing; p = 0.005, n = 9. EF = ejection fraction.
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