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Figure 3 The effect of atorvastatin on vascular endothelial growth factor (VEGF) synthesis by human coronary artery smooth muscle cells (HCASMC) in vitro. The VEGF synthesis in HCASMC (in % of untreated cells). Atorvastatin (1, 3 and 10 µmol/l) decreased basal (*p < 0.003 vs. untreated cells) VEGF production in HCASMC. Interleukin (IL)-1ß (10 ng/ml) induced VEGF synthesis ( p < 0.003 vs. untreated cells) in these cells. Incubation of IL-1ß-treated HCASMC with atorvastatin again decreased the VEGF production (#p < 0.0001 vs. IL-1ß-treated cells).
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