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Figure 3 Reverse transcriptase polymerase chain reaction (RT-PCR) analysis of tumor necrosis factor-alpha (TNF- ) (A), transforming growth factor-beta (TGF-ß1) (B) and interleukin-10 (IL-10) (C) messenger ribonucleic acid (mRNA) expression in the left ventricle 56 days after induction of a moderate-to-large myocardial infarction (MI) or after sham-to-small operation. Drug treatments (omapatrilat 40 mg/kg/day [OMA-40] and captopril 160 mg/kg/day [CAP-160]) were started 4 h after coronary artery ligation. Values are means ± SEM of seven to nine animals in each group. Values (Cytokine-to-glyceraldehyde-3-phosphate dehydrogenase [GAPDH] ratio, derived from RT-PCR) are arbitrary scanning units normalized to sham group = 1. *p < 0.05 vs. sham-to-small;  p < 0.05 vs. MI.
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