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Figure 2 Cardiac specimen image and corresponding gray-scale and color Doppler myocardial imaging (DMI) images of the anterior wall from intracardiac echocardiography. (a) The cardiac specimen was sliced through the plane that included both epicardial markers (arrows) and double-stained with Evans blue and 2,3,5-triphenyltetrazolium chloride. Nonischemic myocardium is stained in blue, ischemic, but viable, myocardium in red and infarcted myocardium in yellow-white. The apex of the heart is toward the left, base of the heart toward right. The white lines correspond with the location of M-mode lines (or gate in pulsed DMI). The yellow polygon indicates the region of interest selected for analysis of the transmural extent of necrosis in the region (transmural extent of necrosis = 100 · number of white pixels / total number of pixels). (b) The corresponding gray scale image shows the location of the epicardial markers, helping in the registration of the gross pathology images with the DMI images. (c) Color DMI frame during ischemia shows tissue velocities during the isovolumic contraction (IVC) period. Note the high-positive velocities in the nonischemic myocardium and negative velocities in the ischemic myocardium. (d) Selected color DMI frame displaying tissue velocities during the ejection phase (at the time of the peak values). Note that the difference in tissue velocities between the normal and ischemic regions is less obvious than it is for IVC tissue velocities.
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