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Figure 5 Effect of anti-interleukin-1ß (IL-1ß) antibody treatment on infarct healing and pro-collagen gene expression. At three days and one week after the operation, collagen accumulation in the infarct-related myocardium was measured as described in the text. Anti–IL-1ß treatment inhibited collagen accumulation in the infarct-related area, which caused a delay in wound healing. Gene expression of type III pro-collagen was suppressed by anti–IL-1ß treatment by one and three days and one week after the operation. There was no significant difference between the vehicle-treated and control (immunoglobulin G [IgG]-treated) groups (four mice in each). Ab = antibody; Col I and III = collagen type I and III, respectively; GADPH = glyceraldehyde-3-phosphate dehydrogenase; n.s. = not significant.
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