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Figure 1 (A) Immunostaining for CD14, a monocyte-specific marker, demonstrated migration of mononuclear cell (MC) isolated from patients with unstable angina (UA) through a Matrigel-coated filter. (B) Bar graphs demonstrate a significant increase (p < 0.05) in the mean migration rates of MCs isolated from patients with UA on comparison with cells isolated from patients with stable angina or normal coronary arteries. No significant shifts in migration rates were detected for lymphocytes. (C) A significant increase in cellular migration rates was detected after treatment with lipopolysaccharide (LPS) for cells isolated from normal donors (p < 0.001) but not for cells isolated from patients with unstable coronary artery disease. Relative MC migration count was obtained by dividing MC cell counts at each LPS dose by untreated control counts. Results are presented as mean cell counts per high power field of all donor samples within a category ± SE. *p  0.05. AMI = acute myocardial infarction; CCS = Canadian Cardiovascular Society; L = lymphocyte; M = monocyte; N = normal; P = pore; SA = stable angina.
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