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Figure 8 Overview of studies using ST resolution (ST RES) to compare standard fibrinolytic therapy with reperfusion regimens containing glycoprotein IIb/IIIa inhibitors and reduced doses of fibrinolytics (combination therapy). In the Integrilin to Minimize Platelet Aggregation and Coronary Thrombosis-Acute Myocardial Infarction (IMPACT-AMI) and Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infarction (PARADIGM) studies, where continuous ST monitoring was performed, combination therapy was associated with more rapid ST recovery than was standard fibrinolytic therapy. In the Thrombolysis In Myocardial Infarction (TIMI) 14 study, where static ST monitoring was performed, combination therapy was associated with a greater likelihood of achieving complete ( 70%) ST resolution, even after limiting the analysis to patients with normal (TIMI grade 3) epicardial blood flow. Pts = patients; TFG3 = TIMI grade 3 flow. Adapted from references 16, 20 and 83.
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