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Figure 4 Single-channel properties of ATP-sensitive K+ channels (KATP) in male and female cardiomyocytes. (A) Continuous recording of KATP activity in membrane patch excised in ATP-free environment from male and female guinea pig cardiomyocytes. Dotted lines represent zero current level, and holding potential was –60 mV. Amplitude (B), open-time (C) and closed-time (D) histograms obtained from A, plotted with a bin width size of 100 µs and fitted by one exponential function. Results of data fitting are plotted as solid lines or closed circles (mean amplitude was 4.06 pA and 4.15 pA for male tissue and female tissue, respectively; mean open time was 1.74 ms and 1.93 ms for male tissue and female tissue, respectively; mean closed time was 0.27 ms and 0.25 ms for male tissue and female tissue, respectively).
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