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Figure 3 Pinacidil-evoked changes in membrane current in male and female cardiomyocytes. (A) Membrane currents evoked by identical families of 400 ms voltage pulses in a cell that was first maintained under control conditions and then exposed to 100 µM pinacidil for 2 min in male and female cardiomyocytes. (B) Currents recorded before and after applications of pinacidil (n = 7) were normalized to input capacitance, and the resultant data are plotted (mean) against membrane potential. Current densities for control and pinacidil-stimulated male and female cardiac cells were determined from the corresponding current-voltage relationship. The pinacidil-sensitive component of current is shown in C for cells in B and current density (D) at 80 mV. Each point/bar represents mean ± SEM (n = 7 for each). *p < 0.05.
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