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Figure 2 Effect of intracoronary enalaprilat (ENAL) and N^G-monomethyl-L-arginine (L-NMMA) on the positive inotropic response to dobutamine (DOB) in patients with dilated cardiomyopathy (DCM) (Groups I and II) and in patients with normal left ventricular function (Group III). Dobutamine was infused intravenously in all groups to achieve +dP/dt >30% above baseline. In Groups I and III, enalaprilat was infused intracoronarily for 15 min before co-infusion with L-NMMA. In Group II, L-NMMA was administered before enalaprilat. Depicted are the percent changes in +dP/dt (open bars) and E_es (single-beat elastance; solid bars) with each drug infusion relative to baseline. *p < 0.05 versus dobutamine and versus L-NMMA. E_es values are only available for two of the five patients in Group II.

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