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Figure 2 Transcript levels of the shear-stress responsive genes endothelial nitric oxide synthase (eNOS), angiotensin-converting enzyme (ACE) and prostacyclin synthase (PGI2S) are unaltered in the skeletal vasculature of patients with chronic heart failure after 12 weeks of physical training. Shown in the graph, transcript levels are normalized to those from the Von Willebrand factor (VWF) gene to control for biopsy-dependent differences in vasculature. Open bars = pretraining; solid bars = posttraining. Data are presented mean ± SEM. Note that the data allow quantitative comparisons pre- and posttraining for each individual gene but do not analyze relative expression of the various genes to each other.
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