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Figure 5 Increased glycolytic substrate during demand ischemia. Ischemia (decreasing coronary perfusion pressure [CPP] to 20 mm Hg) reduced left ventricular systolic pressure (LVSP) to 55 mm Hg and left ventricular end-diastolic pressure (LVEDP) to 16 mm Hg. Tachycardia increased LVEDP to 24 mm Hg, indicating increased diastolic chamber stiffness. High 25 mmol/L glucose (25 mM) and insulin (400 µU/ml) infusion gradually increased LVSP, and concomitantly decreased LVEDP from 24 to 18 mm Hg (i.e., reversed the increase in LV diastolic chamber stiffness produced by demand ischemia), toward pre-tachycardia values.
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