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Figure 2 Transmural distribution of regional perfusion in pigs with hibernating myocardium. Microsphere measurements of perfusion at rest (black circles), during submaximal epinephrine infusion (white diamonds) and during adenosine vasodilation (black squares) are presented for the normal remote region (upper graph) and the hibernating LAD region (lower graph). Flow values for each condition were nearly identical in the LAD and normal regions at each time point. A critical impairment of subendocardial flow reserve was present in each group with vasodilated flow unable to increase over resting values. The degree of vasodilation and the transmural pattern of distribution was the same in each group demonstrating stable coronary physiology over the course of the study. LAD = left anterior descending coronary artery.
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