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Figure 4 Improved endothelium-dependent vasodilation after cerivastatin therapy can be blocked with L-NMMA. Changes in forearm blood flow in percent from baseline ( %) after the infusion of acetylcholine (ACh) 12 µg/min (ACh 12, upper panel) and 48 µg/min (ACh 48, lower panel) without (left two columns) and with (right two columns) coinfusion of the nitric oxide synthase inhibitor L-NMMA 4 µmol/min before (open box) and after (solid box) lipid-lowering therapy with cerivastatin for two weeks. L-NMMA = N(G)-monomethyl-L-arginine.
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