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Figure 3 Reduction of whole-cell ICa by the postischemic coronary effluent. A, ICa recorded from a rat ventricular myocyte before (control; solid circles) and 1 min after adding 1:4 diluted postischemic effluent to the superfusate (open circles). The time-dependent decay of ICa was matched to a double-exponential function (thin solid line; time constants = 4 and 20 ms). B, Plot of peak ICa as a function of the test-step potential (iv curve) before (control; filled circles) and after adding 1:4 diluted postischemic effluent to the superfusate (open circles). The holding potential was –45 mV. Between –40 and 50 mV, voltage dependence of peak ICa is matched, as calculated from the Boltzman formula. Effluent = postischemic coronary effluent (dilution 1:4).
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