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Figure 3 Acetylcholine-mediated changes in coronary sinus platelet cGMP content and coronary blood flow in patients with (n = 11) (dashed lines) and those without (n = 15) (solid lines) epicardial coronary constriction with 10–6mol/l acetylcholine. Baseline coronary blood flow (40.7 ± 9 vs. 43.6 ± 8 ml/min, p = 0.8) and platelet cGMP content (0.72 ± 0.1 vs. 0.83 ± 0.2 pmol/109 platelets, p = 0.6) were not significantly different between patients with epicardial constriction compared to those with dilation in response to acetylcholine. Differences between groups by analysis of variance. cGMP = cyclic guanosine monophosphate.





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