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Figure 1 Effects of MK-0852 on collagen-induced platelet glycoprotein IIb/IIIa receptor activation. Platelet rich plasma from venous blood (i.e., from the ischemic zone) was prepared as described in the Methods section. Some spontaneous platelet aggregation was observed before the addition of collagen (5 µg/mL) in vehicle treated dogs (A); this did not occur after administration of MK-0852 (C). Collagen induced significant platelet aggregation in vehicle treated dogs (B), but this reaction was significantly blunted with MK-0852 treatment (D). MK-0852 = N-acetyl-cys-asn-(5,5-dimethyl-4-thiazolidine-carbonyl)-4-amino-methyl-phe-gly-asp-cys, monoacetate.
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