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Figure 1 (A) The synthesis of ADMA by the cultured human endothelial cell line ECV 304. Data are mean ± SEM for n = 5 to 6 separate experiments. The synthesis rates of ADMA and SDMA were calculated from the mean differences in dimethylarginine concentrations between the experimental days as 0.34 ± 0.17 µmol ADMA/107 cells/24 h and 0.29 ± 0.14 µmol SDMA/107 cells/24 h. (B) The effect of incubating endothelial cells with nLDL or oxLDL on ADMA elaboration. Concentrations of lipoproteins are given as mg/dL in legend. Data are mean of n = 4 to 6 separate experiments. *p < 0.05 versus control. ADMA = asymmetric dimethylarginine; nLDL = native low-density lipoprotein; oxLDL = oxidized low-density lipoprotein; SDMA = symmetric dimethylarginine.
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