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Figure 3 Cerivastatin inhibits human saphenous vein smooth muscle cell growth: PDGF-BB (5 ng/ml, 24 h) enhanced ³H-thymidine incorporation, which was markedly reduced by cerivastatin (10^–6 mol/liter; n = 4). The inhibitory effect of cerivastatin on ³H-thymidine incorporation was only partially reversed by co-incubation of the cells with the HMG-CoA product mevalonate (2 x 10^–4 mol/liter). * = p < 0.01 vs. control; = p < 0.01 vs. PDGF; = p < 0.01 vs. PDGF plus cerivastatin.

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