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Figure 1 Effect of apo E genotype on lipids (mean percent change ± SD) in response to fluvastatin treatment. At 12-week follow-up, the subjects receiving fluvastatin in the 3/4 and 4/4 genotype group had significantly smaller reductions in total cholesterol (TC) (p = 0.01) and LDL cholesterol (p = 0.03) than did subjects in the 3/3 genotype group. For HDL cholesterol, the subjects receiving fluvastatin in the 2/3 genotype group had significantly greater increases than did the subjects in either the 3/3 genotype group (p = 0.002) or the 3/4 and 4/4 genotype group (p = 0.02). There was no significant interaction between treatment and genotype for changes in triglyceride (TG) levels. Solid bar = 2/3 genotype; open bar = 3/3 genotype; shaded bar = 3/4 and 4/4 genotypes.
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