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Figure 3 Graph showing FBF responses to intra-arterial infusion of BQ-123 (100 nmol/min) for 2 h (open circles) and to BQ-123 alone for 1 h followed by the combination with BQ-788 (50 nmol/min) for another hour (closed circles) in six hypercholesterolemic patients. Values represent mean ± SEM. The p value refers to the comparison in FBF changes during selective ETA blockade between the two different occasions (left) and during nonselective ETA/ETB blockade vs. selective ETA blockade (right) by analysis of variance. In the latter comparison, there was no significant interaction between treatment (BQ-123 alone vs. combination of BQ-123 and BQ-788) and time of infusion.
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