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Figure 6 Left panels. Increase in APD90 induced by 293B 10–6 M (open symbols) and 10–5 M (solid symbols) as a function of PCL in (A) endomyocardial biopsies of unaffected (n = 6; circle) and affected dogs (n = 5; triangle) and (B) Purkinje fibers of unaffected (n = 9; circle) and affected dogs (n = 5; triangle). Right panels. Typical action potentials recorded in (C) endomyocardial biopsies and (D) Purkinje fibers of affected dogs (top) and unaffected dogs (bottom) under control conditions (C) and in the presence of 293B 10–5 M (10–5) at PCL = 1,000 ms. Vertical bar, 50 mV; horizontal bars, 100 ms in (C) and 200 ms in (D). APD = action potential duration; PCL = pacing cycle length.
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