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Figure 2 (A) Typical superimposed endomyocardial action potentials recorded in an unaffected dog (left) and an affected dog (right) under control conditions at PCL = 1,000 ms and PCL = 8,000 ms. Vertical bar, 50 mV; horizontal bar, 100 ms. (B) Effects of PCL on APD at 30% (left) and 90% (right) of full repolarization (APD30 and APD90) of endomyocardial biopsies obtained from 17 unaffected dogs (n = 25 samples, open circle) and 12 affected dogs (n = 30 samples, open triangle) under control conditions. In both graphs, the two curves are significantly separated (two-way analysis of variance). APD = action potential duration; PCL = pacing cycle length.
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