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Figure 4 Changes in the expression of platelet activation epitopes after administration of aspirin (100 mg/day, black bars), clopidogrel (75 mg/day, white bars) and aspirin (100 mg/day) plus clopidogrel (75 mg/day, hatched bars). In figures A to C, platelets were stimulated with adenosine diphosphate (ADP; 0.01, 0.1, 1, 10, 100 µmol/L) and in D to F with thrombin (0.01, 0.05, 0.1, 0.5 U/mL). After stimulation, activated platelets were detected by flow cytometry with monoclonal antibodies directed against CD62p (P-selectin), which recognizes alpha-granule release, CD63 recognizing lysosome secretion and PAC-1 detecting activated GP IIb-IIIa complex. Results (n = 30) are expressed as the percentage of the total platelet population binding each monoclonal antibody and represent mean ± SEM. *p < 0.05 versus aspirin; #p < 0.05 versus clopidogrel;  p = 0.054; ¶p = 0.065 versus clopidogrel (Wilcoxon signed rank test).
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