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Figure 4 Mean changes from baseline in sitting systolic (A) and diastolic (B) BP after GTN administration. Sildenafil plus GTN caused significant decreases in systolic and diastolic BP compared with placebo plus sildenafil. Sublingual GTN (500 µg) was administered 1 h after oral sildenafil (50 mg), as indicated by the arrow. Baseline (time 0) is the average of the measurements taken immediately before sildenafil or placebo administration. Values represent mean ± SEM; n = 15; BP = blood pressure; GTN = glyceryl trinitrate.
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