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Figure 5 Intercellular adhesion molecule-1, P-selectin and VAP-1 mediate granulocyte adhesion to vessels in infarcted heart. a) In this dark field picture two cardiac vessels (dashed lines) are shown, one with seven bound granulocytes and the other supporting the binding of two granulocytes (arrows). b) Anti-VAP-1, P-selectin and anti-ICAM-antibodies separately or in combination decrease the number of granulocytes adhering to myocardial blood vessels when compared with the specimens treated with nonbinding (set as 100%) control antibodies or without any antibodies (–). ICAM = intercellular adhesion molecule; VAP-1 = vascular adhesion protein-1.
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