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Figure 4 Mean regional percent left ventricular wall thickening in dogs with smaller infarct size (group 1) (A) and with larger infarct size (group 2) (B). There was a significant difference in wall thickening between the LAD and normal LCx zones in both groups (p < 0.01, respectively). Thickening in the LCx zone (dashed lines) was stable before dobutamine infusion and increased during dobutamine infusion in both groups. In the LAD zone (solid lines), thickening was absent in both groups after reperfusion. Note that after graded dobutamine infusion, thickening in the LAD zone markedly increased in group 1 dogs and was not significantly different from normal LCx zone thickening at 20 and 30 µg·kg–1·min–1 dobutamine infusion. In contrast, group 2 dogs showed a significant attenuation of inotropic reserve in the LAD zone. Base = baseline; Full = full reperfusion; LAD = left anterior descending coronary artery; LCx = left circumflex coronary artery; Occ = occlusion; Part = partial reperfusion; Sten = stenosis; *p < 0.05 vs. LCx;  p < 0.01 vs. LCx.
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