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Figure 3 Light micrographs from frozen sections of endomyocardial biopsy from patient #13, with deletions of exons 6–8, 12, 13, 16, 17, 19 and 44. The immunostain of rod domain (a) and N-terminus (c) is almost absent: only sporadic, possibly revertant fibers retain immunoreactivity; the expression of C-terminus is discontinuous or absent in some cells (b). Alpha (d) and gamma (e) sarcoglycan immunostains show focal interruptions and irregular intensity; beta dystroglycan (f) only shows minimal decrease. Merosin (g) is normally expressed. (Fluorescein-conjugated rabbit antimouse antibodies; a–g 280x, reduced by 60%).
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