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Figure 2 Time course of lactate production. Cardiac myocytes were incubated with (a) 10–4 mol/liter or 10–3 mol/liter sodium nitroprusside (SNP), (b) 10–4 mol/liter or 10–3 mol/liter 8-bromo cGMP, or (c) 10 ng/ml IL-1ß (IL) in the presence or absence of 3 mmol/liter NG-monomethyl-L-arginine (L-NMMA) for the indicated time, and lactate production was measured in the media as described in Methods. Control preparations contained no additives. The interaction between seven groups and time course was significant (p < 0.0001).  p < 0.0001 vs. control (n = 6).
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