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Figure 6 Regional diastolic stiffness ({alpha}) for lased and nonlased regions after TMR with (A) holmium:YAG and (B) CO2 lasers. Values of {alpha} are expressed as a percent of baseline values in the lased and nonlased regions (normalized), with baseline values assigned a value of 100%. Higher values indicate increasing myocardial stiffness. Note the significant increase in {alpha}, indicating impaired diastolic relaxation in the lased regions by 6 h post-TMR with both holmium:YAG (1 h: 183.3 ± 56.3% baseline; 6 h: 217.4 ± 44.2% baseline) (absolute {alpha} values: baseline 67.1 ± 18.5, 1 h 84.4 ± 10.8, 6 h 117.5 ± 9.9) and CO2 (1 h: 112.4 ± 24.7% baseline; 6 h: 206.0 ± 36.7% baseline) (absolute {alpha} values: baseline 65.3 ± 17.3, 1 h 60.3 ± 10.5, 6 h 120.1 ± 22.8) lasers. There was no change in {alpha} for the nonlased regions after either holmium:YAG (1 h: 76.2 ± 19.1% baseline; 6 h: 99.5 ± 15.2% baseline) (absolute {alpha} values: baseline 71.1 ± 5.4, 1 h 53.9 ± 15.6, 6 h 70.8 ± 13.3) or CO2 (1 h: 93.6 ± 19.7% baseline; 6 h: 112.8 ± 32.9% baseline) (absolute {alpha} values: baseline 119.0 ± 21.6, 1 h 104.2 ± 20.9, 6 h 118.4 ± 22.0) TMR. Closed diamond = lased; open square = control. A: *p = 0.05 vs. baseline; B: *p = 0.03 vs. baseline.





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