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Figure 2 Effects of pretreatment with L-NMMA, a NOS inhibitor, on BH4-induced vasodilation in smokers. Infusion of L-NMMA into the brachial artery significantly decreased FMV in smokers (top) (p = 0.0008 by post hoc analysis), but did not affect GTN-induced vasodilation (bottom). The increase (top) (p = 0.0007 by post hoc analysis) in FMV induced by sapropterin 3 h after administration was abolished by pretreatment with L-NMMA (before vs. after sapropterin, p = 0.002 for the interactions by ANOVA).
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