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Figure 1 Effects of simvastatin (2 µmol/liter) on the growth inhibition of rat VSMCs. In treated rats simvastatin (open boxes) induced a significant inhibition of VSMC proliferation as compared with control rats (solid diamonds). This effect was completely reversed by addition of mevalonate (100 µmol/liter) to the medium (open circles), but it was not affected by addition of 25-OH-cholesterol (100 µg/ml) (solid triangles). *p < 0.01 vs. control rats and simvastatin plus mevalonate treatment.
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