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Figure 7 Effect of poly-I on lipoprotein and 5HT induced VSMC proliferation. Synchronized VSMCs were stimulated with different concentrations of LDL or mox-LDL in the presence or absence of 25 µg/mL of poly-I. After 24 h of incubation with LDL or mox-LDL, 50 µmol/L of 5HT was added and incubated for an additional 24 h. One hundred percent equals the baseline value for 3H-thymidine incorporation into DNA (274 ± 18 cpm). Values shown are mean ± standard error. poly-I = polyinosinic acid. All other abbreviations as in Figure 2. n = 10; *p < 0.05 compared with corresponding control; **p < 0.05 compared with corresponding lipoprotein group.
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