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Figure 2 Pressure-time (upper panels), dP/dt-time (middle panels) and dP/dt-P plots (lower panels) from representative beats in normal, HCM and DCM hearts. Monoexponential fits are shown by dashed lines and logistic fit by solid lines in each instance. P(t) data were well fit in all instances by both models. However, in DCM patients, the ME model did not predict dP/dt data well, and in all cases the logistic model better predicted this derivative. The lower plots synthesize these two behaviors, with ME fits appearing as a straight line, and logistic fits as a parabola. The latter better approximated the measured data—most notably in DCM ventricles. DCM = dilated cardiomyopathy; HCM = hypertrophic cardiomyopathy; ME = monoexponential.
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