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Figure 1 The effects of prostacyclin on (A) pulmonary artery pressure, (B) cardiac output, and (C) pulmonary vascular resistance are shown at baseline, after chronic treatment, and after the dose was reduced. Although prostacyclin chronically lowered the pulmonary artery pressure and raised the cardiac output, acutely reducing the prostacyclin dose affected only the cardiac output. *p < 0.001 vs. baseline; **p < 0.002 vs. baseline;  p < 0.001 vs. prostacyclin.
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