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Figure 1 Thrombin generation (F1.2 concentrations) at baseline, 1 h, 4 h and 24 h for the overall patient population and patients randomized to either immediate discontinuation of heparin (D/C heparin), intravenous (IV) heparin weaning or subcutaneous (SC) heparin weaning. Thrombin generation was evident by 1 h and increased steadily over time. Thrombin generation was greatest with abrupt heparin cessation and was least with IV heparin weaning. D/C = discontinue; IV = intravenous; SC = subcutaneous.
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