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Figure 1 Schematic illustration of potential interactions of angiotensin-converting enzyme (ACE) inhibitors, bradykinin and aspirin on vascular prostacyclin (PGI2) production. Whether inhibition of vascular cyclooxygenase by antiplatelet doses of aspirin attenuates bradykin-induced prostaglandin-mediated vasodilation in response to ACE inhibition is uncertain. ATII = angiotensin II; + = stimulatory effect; – = inhibitory effect; ? = uncertain effect.
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