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Figure 6 Effect of co-incubation of human left ventricular myocardial preparations for 6 h either with lipopolysaccharides (1 µg/ml, n = 5), with lipopolysaccharides and the radical-scavenger Tiron (10 mmol/liter, n = 5), with Tiron (10 mmol/liter, n = 5) alone or in normal Tyrode (control, n = 5). Upper panel shows the concentration-dependent positive inotropic effect of isoprenaline. Ordinate gives force of contraction in mN, abscissa gives isoprenaline concentrations in µmol/liter. Bar graph in the lower panel summarizes the maximum isoprenaline effects on isometric force of contraction in the different groups.
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