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Figure 1 Effect of treatment of isolated human left ventricular myocardial preparations from terminally failing hearts with lipopolysaccharides (Endo, 1 µg/ml) on the concentration-dependent inotropic response to isoprenaline. Upper panel shows the effect of 6 h and lower panel the effect of 12 h of incubation. Also, the effects of co-incubation of isolated myocardial preparations with either L-NMMA (100 µmol/liter) or hemoglobin (Hb, 2 µg/ml) are demonstrated. Ordinate gives force of contraction in mN, abscissa concentration of isoprenaline in µmol/liter. Data are given as mean ± SEM.
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