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Figure 4 Platelet studies. Peripheral blood samples obtained pre- and postangioplasty were compared (paired t test). (a) Platelet P-selectin (CD62) expression in the control group increased (n = 25, p < 0.05), while platelet P-selectin (CD62) expression decreased in the chimeric 7E3 group (n = 25, p < 0.05). Preprocedure platelet P-selectin (CD62) expression was higher and postprocedure platelet P-selectin (CD62) expression was lower in the chimeric 7E3 Fab group than the control group (p < 0.01). (b) Platelet GP IIb/IIIa expression (as detected by anti-CD41a) in the control group increased (n = 25, p < 0.05), while the GP IIb/IIIa receptor was not accessible to the anti-CD41a in the chimeric 7E3 group (n = 25, p < 0.0001).
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