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Figure 2 (A) Change after 12 weeks of treatment in plasma norepinephrine concentrations (in pg/ml), at rest (open bars) and peak exercise (solid bars). There are no significant differences. (B) Change after 12 weeks of treatment in plasma renin (µU/ml), at rest (open bars) and peak exercise (solid bars). *p < 0.05 vs. placebo; **p < 0.001 vs. placebo; #p < 0.05 vs. 2.5-mg imidapril. The dose-response relation was significant both at rest and during exercise (p < 0.05 by linear trend). (C) Change after 12 weeks of treatment in plasma ACE (in % from baseline), at rest (open bars) and peak exercise (solid bars). All differences are highly significant vs. placebo (p < 0.001) but there is no dose-response relation. (D) Change after 12 weeks of treatment in plasma BNP (pg/ml), at rest (open bars) and peak exercise (solid bars). *p < 0.05 vs. placebo. The effect on BNP is dose-dependent, both at rest and during exercise (both p < 0.05).
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