HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Figures Only Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Joris, J. L. Articles by Lamy, M. L. Search for Related Content PubMed PubMed Citation Articles by Joris, J. L. Articles by Lamy, M. L.

CLINICAL STUDIES

Hemodynamic changes induced by laparoscopy and their endocrine correlates: effects of clonidine

Jean L. Joris, MD^*, Jean-Daniel Chiche, MD^*, Jean-Luc M. Canivet, MD^*, Nicolas J. Jacquet, MD, Jean Jacques Y. Legros, MD and Maurice L. Lamy, MD^*

^* Department of Anesthesiology and Intensive Care Medicine, University Hospital of Liège, Liège, Belgium
Department of Gastrointestinal Surgery, University Hospital of Liège, Liège, Belgium
Department of Endocrinology, University Hospital of Liège, Liège, Belgium

Manuscript received April 13, 1998; revised manuscript received June 25, 1998, accepted July 15, 1998.

Address for correspondence: Dr. Jean Joris, Department of Anesthesiology and Intensive Care Medicine, CHU of Liège, Domaine du Sart Tilman, B-4000 Liège, Belgium
mlamy{at}chu.ulg.ac.be

	Abstract

Top Abstract Methods Results Discussion References

 
Objectives. We investigated endocrine correlates of the hemodynamic changes induced by carbon dioxide pneumoperitoneum (PNO). We then studied whether clonidine might modulate the hemodynamic changes induced by PNO by reducing release of catecholamines and vasopressin.

Background. Both mechanical and neurohumoral factors contribute to the hemodynamic changes induced by carbon dioxide PNO. Several mediators have been proposed, but no study has correlated hemodynamic changes with changes in levels of these potential mediators.

Methods. We conducted two studies, each including 20 healthy patients scheduled for elective laparoscopic cholecystectomy. In the first study serial measurements of hemodynamics (thermodilution technique) were done during laparoscopy and after exsufflation. Plasma concentrations of cortisol, catecholamines, vasopressin, renin, endothelin and prostaglandins were measured at the same time points. In the second study patients were randomly allocated to receive 8 µg/kg clonidine infused over 1 h or placebo before PNO. Hemodynamics and plasma levels of cortisol, catecholamines and vasopressin were measured during PNO and after exsufflation.

Results. Peritoneal insufflation resulted in a significant reduction of cardiac output (18 ± 4%) and increases in mean arterial pressure (39 ± 8%) and systemic (70 ± 12%) and pulmonary (98 ± 18%) vascular resistances. Laparoscopy resulted in progressive and significant increases in plasma concentrations of cortisol, epinephrine, norepinephrine and renin. Vasopressin plasma concentrations markedly increased immediately after the beginning of PNO (before PNO 6 ± 4 pg/ml; during PNO 129 ± 42 pg/ml; p < 0.05). The profile of vasopressin release paralleled the time course of changes in systemic vascular resistance. Prostaglandins and endothelin did not change significantly. Clonidine significantly reduced mean arterial pressure, heart rate and the increase in systemic vascular resistance. Clonidine also significantly reduced catecholamine concentrations but did not alter vasopressin and cortisol plasma concentrations.

Conclusions. Vasopressin and catecholamines probably mediate the increase in systemic vascular resistance observed during PNO. Clonidine before PNO reduces catecholamine release and attenuates hemodynamic changes during laparoscopy.

Abbreviations and Acronyms   ASA = American Society of Anesthesiologists   HR = heart rate   MAP = mean arterial pressure   PCO2 = partial pressure of carbon dioxide   PCWP = pulmonary capillary wedge pressure   PGE2 = prostaglandin E2   PNO = pneumoperitoneum   PVR = pulmonary vascular resistance   RAP = right atrial pressure   SO2 = mixed venous blood oxygen saturation   SVR = systemic vascular resistance

Both mechanical and neurohumoral factors contribute to these hemodynamic changes (2,4). Several mediators have been proposed: catecholamines (5,6), prostaglandins (7), renin (8) and vasopressin (9–11). Unfortunately, no study has correlated hemodynamic changes with changes in levels of these potential mediators. Therefore, we first investigated endocrine correlates of the hemodynamic changes induced by PNO during laparoscopic cholecystectomy in healthy patients. Interestingly, alpha₂-adrenergic agonists have been shown to improve hemodynamic stability during gynecologic laparoscopy (12,13). Moreover, clonidine inhibits the release of catecholamines (14) and also blocks the release of vasopressin in dogs (15). We therefore tested the hypothesis that clonidine might attenuate the hemodynamic changes induced by PNO by reducing release of these substances.

	Methods

Top Abstract Methods Results Discussion References

 
Two studies were conducted after our institution’s Ethics Committee gave approval and after patients gave their informed consent. Patients in each study were scheduled for elective laparoscopic cholecystectomy. Inclusion criteria were body weight no more than 20% above ideal weight, age between 18 and 70 years, absence of acute cholecystitis and no cardiorespiratory disease or medications. We used the same anesthetic technique in both studies. All patients were given 50 mg hydroxyzine orally 2 h before surgery and an intramuscular injection of 5 mg midazolam and 0.25 mg atropine before transfer to surgery. General anesthesia was induced with 15 µg sufentanil and 5 mg/kg thiopental. After orotracheal intubation facilitated with 0.5 mg/kg atracurium, anesthesia was maintained with 50% nitrous oxide in oxygen and isoflurane. Isoflurane concentrations were adapted to maintain hemodynamic stability by an experienced anesthesiologist; mean arterial pressure (MAP) was not allowed to increase more than 20% above preinduction value. In addition to clinical signs, the anesthesiologist used routine monitoring for laparoscopic cholecystectomy (i.e., automated oscillometric arterial blood pressure, electrocardiogram, capnography and pulse oximetry), but was unaware of the information derived from the invasive monitoring described below as well as of the arterial blood gas analyses. During surgery minute ventilation was controlled (Servo 900C; Siemens Elema, Stockholm, Sweden) and adjusted to keep the expired end-tidal partial pressure of carbon dioxide (PCO₂) between 30 and 40 mm Hg. Respiratory rate was kept constant at 10-min. During laparoscopy intraabdominal pressure was automatically maintained at 14 mm Hg by a carbon dioxide insufflator (Richard Wolf; Knittlingen, Germany).

Study 1: hemodynamic data and endocrine correlates.   Twenty American Society of Anesthesiologists (ASA) patients in physical status 1 and 2 were included in this study. Fasting and intraoperative fluid losses were compensated by a continuous intravenous infusion ( 5 ml·kg^–1·h^–1) of lactated Ringer’s solution.

Hemodynamic and metabolic parameters
A radial artery was cannulated and a 7.5F thermodilution pulmonary artery catheter was introduced via the right internal jugular vein before induction of anesthesia. The following parameters were recorded on a Datex AS/3 monitor (Datex-Engström, Helsinki, Finland): MAP, right atrial pressure (RAP), pulmonary artery pressure and pulmonary capillary wedge pressure (PCWP) as well as HR. Cardiac output was measured by the Datex AS/3 monitor using the average of three measurements made at the end of expiration. Systemic vascular resistance and PVR were automatically computed by the Datex AS/3 monitor. Data were collected before the induction of anesthesia; 10 min after the induction of anesthesia; 10 min after tilting into a 10° head-up position; 5, 15 and 30 min after the beginning of insufflation; and finally 30 min after exsufflation. At this last time point anesthesia had been terminated for approximately 15 min and the patients, extubated, were breathing spontaneously in the horizontal position. The pressure transducer was located at the level of the right atrium and was moved after tilting to remain at this level. At the same time points arterial and mixed venous blood samples were drawn for blood gas analysis (288 Blood Gas System; Ciba Corning Diagnostics Corp., Medfield, Massachusetts). Oxygen transport and oxygen consumption were calculated according to standard formulas. Plasma lactate concentrations were also measured (Socolab, Limal, Belgium).

Endocrine parameters.   Arterial blood samples were collected at the same time points as above for assay of the following hormones: cortisol (Radim, Liège, Belgium); catecholamines (16); renin (ERIA Diagnostics Pasteur, Marne la Coquette, France); endothelin (Amersham International, Amersham, United Kingdom); vasopressin (Bühlmann Laboratories AG, Basel, Switzerland); vasopressin–neurophysin (17); and prostaglandin E₂ (PGE₂), 6-keto-PGF₁ (a metabolite of prostacyclin) and TxB₂ (a metabolite of thromboxane) (Cayman Chemical, Ann Arbor, Michigan). Cortisol was used as an index of intraoperative stress; the other hormones were selected for their known vasoactive properties. Vasopressin–neurophysin, released concomitantly with vasopressin, is more stable in the blood than the active nonapeptide. The assay of the inactive peptide was used to validate measured plasma concentrations of vasopressin.

Study 2: effects of clonidine on hemodynamic and endocrine changes.   After the induction of anesthesia, 20 ASA physical status 1 and 2 patients were randomly allocated to receive either 8 µg·kg^–1 clonidine intravenously over 1 h or the same volume of saline placebo in a double-blind fashion. This dose of clonidine was selected to approach doses reported to inhibit vasopressin release in animal studies (15). To avoid potential severe hypotension as a result of clonidine treatment, all patients received 500 ml lactated Ringer’s solution before the induction of anesthesia and peritoneal insufflation was initiated with the patient in the horizontal position. Intraoperatively, the intravenous infusion of lactated Ringer’s solution was 5 ml·kg^–1·h^–1. Because invasive monitoring was performed after the induction of anesthesia to avoid patient discomfort, preoperative cardiac function was assessed, using transthoracic echocardiography, on the day before surgery by the same investigator (J.L.C.), who was unaware of the patient allocation group.

Hemodynamic and metabolic parameters
The same hemodynamic parameters as in the first part of the study were recorded. Data were collected at the end of the infusion of clonidine or placebo and before induction of the PNO, 5 min after the beginning of peritoneal insufflation with the patient in supine position, 15 and 30 min after the beginning of insufflation with the patient tilted to a 10° head-up position, 5 min after exsufflation with the patient still tilted to a 10° head-up position, and finally 30 min after exsufflation, approximately 15 min after the end of anesthesia and tracheal extubation with the patient in horizontal position breathing spontaneously. Mixed venous blood oxygen saturation (SO₂) was also measured at the same time points.

Endocrine parameters
Arterial blood samples were collected at the same time points to assay plasma cortisol, catecholamine and vasopressin concentrations. Plasma clonidine concentrations were also assayed 5 min after the beginning of peritoneal insufflation with the patient in supine position using a radioimmunoassay. The sensitivity was 0.1 ng/ml with a coefficient of variation of <15%.

Statistical analysis.   Results are reported as mean ± SEM. Data were analyzed by one-way analysis of variance for repeated measures followed by Scheffé’s test for multiple comparisons (study 1). Because distributions were not normal at some time points (from 5 min after the beginning of peritoneal insufflation until approximately 15 min after the end of anesthesia extubation) for epinephrine, norepinephrine and vasopressin, analysis was applied after logarithmic transformation. In the second study demographic data were compared using the unpaired Student t test. To assess the effect of clonidine, data were analyzed by two-way analysis of variance for repeated measures followed by the Newman–Keuls’ test. Results were considered to be statistically significant at the 5% critical level.

	Results

Top Abstract Methods Results Discussion References

 
Study 1.   Morphometric characteristics of the patients were: age 46 ± 5 years, sex (F/M) 14/6, weight 67 ± 4 kg and height 164 ± 3 cm. The duration of PNO was 67 ± 7 min. After the induction of anesthesia cardiac output decreased (Table 1). Tilting the patient to a 10° head-up position resulted in a significant decrease in RAP and PCWP. Consequently, cardiac output and MAP further decreased. Peritoneal insufflation at 5 min resulted in a significant reduction (18 ± 4%) of cardiac output, and a rise of MAP (39 ± 8%). Right atrial pressure and PCWP were significantly increased during PNO. Systemic and pulmonary vascular resistances also increased after peritoneal insufflation (SVR 70 ± 12%, PVR 98 ± 18%). Concentrations of isoflurane were increased to correct the increases in MAP. Simultaneously, partial correction of cardiac output, SVR and PVR occurred. However, these variables remained significantly different from preoperative values during PNO. After exsufflation all hemodynamic parameters returned to preoperative values (Table 1).

1

View larger version (29K): [in this window] [in a new window]   Figure 1 Changes in SVR as well as in plasma concentrations of vasopressin and neurophysin during laparoscopic cholecystectomy (study 1). Systemic vascular resistance was calculated and arterial blood samples were collected before the induction of anesthesia (PRE-IND); 10 min after the induction of anaesthesia (POST-IND); 10 min after tilting into a 10° head-up position (HEAD-UP); 5 min (PNP 5), 15 min (PNP 15) and 30 min (PNP 30) after the beginning of insufflation; and 30 min after exsufflation (END). Results are mean ± SEM. *p < 0.05 compared with PRE-IND; p < 0.05 compared with HEAD-UP.

View larger version (37K): [in this window] [in a new window]   Figure 2 Effect of 8 µg/kg clonidine infused over 1 h before peritoneal insufflation on hemodynamic changes induced by carbon dioxide PNO (study 2). Mean arterial pressure, heart rate, cardiac output and systemic vascular resistance were measured or calculated at the end of the infusion of clonidine or placebo and before the creation of the PNO (PRE-PNO); 5 min after the beginning of peritoneal insufflation with the patient in the supine position; 15 and 30 min after the beginning of insufflation with the patient tilted to a 10° head-up position; 5 min after exsufflation with the patient still tilted to a 10° head-up position (EXS-5); and finally 30 min after exsufflation, approximately 15 min after the end of anesthesia and tracheal extubation with the patient in a horizontal position breathing spontaneously (END). Results are mean ± SEM. *p < 0.05 compared with placebo; the increase in SVR was significantly (p < 0.05) less in the clonidine group (+394 ± 113 dynes·s·cm–5) than in the placebo group (+745 ± 49 dynes·s·cm–5); p < 0.05 compared with PNO 30 min.

View larger version (34K): [in this window] [in a new window]   Figure 3 Effect of 8 µg/kg clonidine infused over 1 h before peritoneal insufflation on endocrine changes induced by carbon dioxide PNO (study 2). Vasopressin, epinephrine, norepinephrine and cortisol were measured at the same time points as in Figure 2. Results are mean ± SEM. *p < 0.05 compared with placebo.

	Discussion

Top Abstract Methods Results Discussion References

Changes in cardiac output.   In both studies cardiac output significantly decreased shortly after the beginning of peritoneal insufflation. The subsequent increase in cardiac output probably resulted from surgical stress, as reflected by increased concentrations of cortisol. Therefore, during PNO for operative laparoscopy, impairment of hemodynamic status occurs mainly at the beginning of peritoneal insufflation. Mixed venous blood oxygen saturation in both studies, as well as plasma lactate concentrations in study 1, remained normal intraoperatively. These findings suggest that changes in cardiac output occurring during PNO are well tolerated by healthy patients.

Because we only included healthy patients in this study, the decrease in cardiac output observed during PNO probably related to a reduction in preload. Pneumoperitoneum results in caval compression (18), an increase in venous resistance (19) and pooling of blood in the peripheral circulation (20). All these effects contribute to decreased venous return. A decline in venous return was confirmed by a reduction in left ventricular end diastolic volume, measured using transesophageal echocardiography (21). The paradoxical increase in RAP and PCWP after insufflation (2,4,22,23) can be explained by the increased intrathoracic pressure associated with PNO (4,11). Therefore, during PNO, RAP and PCWP can no longer be considered reliable indexes of cardiac filling pressures.

Increase in SVR.   All studies reported to date describe an increase in SVR during PNO. This increase in afterload cannot be simply considered a reflex sympathetic response to decreased cardiac output. Indeed, SVR also increased in studies where no decrease in cardiac output was reported (24,25). Although the normal heart tolerates increases in afterload under physiologic conditions, the changes in afterload produced by PNO can result in deleterious effects in patients with cardiac diseases and may contribute to a further decrease in cardiac output (26). The increase in SVR is considered to be mediated by mechanical and neurohumoral factors (2,4,7), and the role of mechanical factors might not be predominant. Indeed, in the second study no changes in SVR were observed 5 min after exsufflation. Instead, correction of these hemodynamic changes was gradual and took several minutes, suggesting involvement of neurohumoral factors (2,7).

Endocrine correlates of the hemodynamic changes.   The profile of vasopressin release in the first study correlated most closely with changes in SVR. Induction of PNO resulted in a rapid and marked release of vasopressin in both studies. This finding was confirmed by the release of neurophysin. The longer half-life of neurophysin explains why plasma neurophysin concentrations plateaued after the induction of PNO. Increases in plasma vasopressin levels were correlated with changes in intraabdominal pressure, intrathoracic pressure and transmural RAP (11). Mechanical stimulation of peritoneal receptors also resulted in increases of vasopressin release (27), SVR and arterial pressure (28). However, whether increasing intraabdominal pressure to 14 mm Hg is sufficient to stimulate these receptors is unknown. Plasma concentrations of vasopressin measured in our two studies were high, and of a magnitude similar to those reported during acute hemodynamic stimulation (e.g., massive hemorrhage). This is important because vasopressin is a potent vasopressor even at normal physiologic concentrations (29). Other mediator(s) are implicated in the increase in SVR. Indeed, although clonidine did not significantly affect plasma vasopressin concentrations, it attenuated the increase in SVR.

Catecholamines, and more particularly norepinephrine, which was also released early during PNO, might contribute to the increase in afterload. Accordingly, clonidine, which significantly reduced the release of catecholamines and almost completely blocked norepinephrine release, attenuated the increase in SVR. The stimulus for catecholamine release during PNO cannot be determined from these studies. Hypercarbia and surgical stress were probably not causes of the initial increase in epinephrine and norepinephrine because PaCO₂ was kept within physiologic limits, and plasma cortisol levels had not yet changed at 5 min of PNO in both studies. The gradual increase in plasma catecholamine concentrations observed later intraoperatively may be correlated with surgical stress, as reflected by increasing plasma concentrations of cortisol, and may contribute to the intraoperative improvement of cardiac output.

In study 1 the plasma concentration of renin was already increased before insufflation, probably in response to decreased venous return secondary to the head-up position and subsequent hypotension. Five minutes after the beginning of insufflation, even though SVR had reached its peak, no significant further increase was observed. The contribution of renin to the initial increase in afterload is therefore questionable. During PNO the progressive increase in plasma renin concentration might be related to activation of the sympathetic system and to surgical stress (30). Furthermore, renin secretion may also result from reduction of glomerular filtration and renal plasma flow induced by PNO (31,32). Finally, prostacyclin, PGE₂, TxB₂ and endothelin did not seem to contribute to the hemodynamic changes induced by PNO.

Effects of clonidine on hemodynamic and endocrine changes.   In the second study we used clonidine to modulate hormone release, more particularly catecholamines and vasopressin, with an aim to improving our understanding of the pathogenesis of the hemodynamic changes induced by PNO. Clonidine improves intraoperative and postoperative hemodynamic stability during laparoscopy, similar to what is seen during general surgery (33,34). Clonidine smoothed the changes in arterial pressure, HR, SVR and cardiac output. These benefits are mediated by a reduction of neurohormonal secretion secondary to stress-induced sympathoadrenal hyperactivation (33–36). Accordingly, plasma catecholamine concentrations were significantly lower in the clonidine group. Inversely, clonidine had no effect on cortisol or vasopressin release in our study. The effect of clonidine on plasma cortisol levels seems to be controversial in humans (37–42). However, stress-induced release of cortisol (40–42), such as during anesthesia and surgery (42), is not affected by clonidine. The effect of clonidine on vasopressin secretion is also controversial (35). Differences in species, route of administration and doses may explain these discrepancies. Because the characteristics of vasopressin release depend on the factor triggering its release (changes in osmolarity, hypovolemia, hypotension, etc.) (43), the effect of clonidine on vasopressin might also be stimulus specific. Nevertheless, our findings suggest that high doses of clonidine given intravenously have no effect on vasopressin release during laparoscopy. Because clonidine potentiates anesthetic agents (33,35,44), isoflurane requirements were significantly reduced in the clonidine group.

Effects of fluid load on hemodynamic changes.   Comparison of our two studies confirms the influence of intravascular volume status on the hemodynamic changes induced by PNO (19,45,46). Compared with the patients of study 1, patients of study 2 were preloaded with 500 ml lactated Ringer’s solution, and insufflation was performed in the supine position instead of the head-up position. Although cardiac output and SVR were similar in study 1 after the induction of anesthesia and in the placebo group of study 2 before induction of PNO (Table 1, Fig. 2), PNO after 5 min resulted in a greater decrease in cardiac output in study 1 (36 ± 5% in study 1 versus 7 ± 5% in study 2) and a higher increase in SVR in study 1 (71 ± 9% in study 1 versus 57 ± 10% in study 2). Subsequently, cardiac output remained lower and SVR greater in study 1 than in study 2, despite similar levels of anesthesia (isoflurane concentrations were similar in both studies). These results provide further evidence that increasing cardiac filling pressures before peritoneal insufflation by fluid loading, followed by tilting the patient to the head-up position only after insufflation, attenuates hemodynamic changes induced by PNO.

In conclusion, the carbon dioxide PNO required for laparoscopy results in multiple hemodynamic changes. These changes were, however, well tolerated by healthy patients. Pneumoperitoneum induced increases in arterial pressure and systemic and pulmonary vascular resistances and a decrease in cardiac output. Both mechanical (increased intraabdominal pressure) and humoral factors contributed to these changes. Vasopressin and catecholamine release probably mediated the increase in SVR. Clonidine and fluid loading before peritoneal insufflation attenuated these hemodynamic changes. Further studies are needed to determine the ideal dose of clonidine. This information should be helpful in safely managing high-risk cardiac patients, thereby allowing these patients to benefit from all the postoperative advantages of the laparoscopic approach.

	References

Top Abstract Methods Results Discussion References

 

1. Joris J. Anesthetic management of laparoscopy. Miller RD. Anesthesia. New York: Churchill Livingstone; 1994. p. 2011–2029
2. Wahba RWM, Beique F, Kleiman SJ. Cardiopulmonary function and laparoscopic cholecystectomy. Can J Anaesth. 1995;42:51–63[Abstract/Free Full Text]
3. Sharma KC, Brandstetter RD, Brensilver JM, Jung LD. Cardiopulmonary physiology and pathophysiology as a consequence of laparoscopic surgery. Chest. 1996;110:810–815[Free Full Text]
4. Joris JL, Noirot DP, Legrand MJ, Jacquet NJ, Lamy ML. Hemodynamic changes during laparoscopic cholecystectomy. Anesth Analg. 1993;76:1067–1071[Abstract/Free Full Text]
5. Mealy K, Gallagher H, Lennon F, Traynor O, Hyland J. Physiological and metabolic responses to open and laparoscopic cholecystectomy. Br J Surg. 1992;79:1061–1064[Medline]
6. Hirvonen EA, Nuutinen LS, Vuolteenaho O. Hormonal responses and cardiac filling pressures in head-up or head-down position and pneumoperitoneum in patients undergoing operative laparoscopy. Br J Anaesth. 1997;78:128–133[Abstract/Free Full Text]
7. Torrielli R, Cesarini M, Winnock S, Cabiro C, Mene JM. Modifications hémodynamiques durant la coelioscopie: étude menée par bioimpédance électrique thoracique. Can J Anaesth. 1990;37:46–51[Abstract/Free Full Text]
8. O’Leary E, Hubbard K, Tormey W, Cunningham AJ. Laparoscopic cholecystectomy: hemodynamic and neuroendocrine responses after pneumoperitoneum and changes in position. Br J Anaesth. 1996;76:640–644[Abstract/Free Full Text]
9. Le Roith D, Barn H, Nyska M, Glick SM. The effect of abdominal pressure on plasma antidiuretic hormone levels in the dog. J Surg Res. 1982;32:65–69[CrossRef][Medline]
10. Punnonen R, Viinamäki O. Vasopressin release during laparoscopy: role of increased intra-abdominal pressure. Lancet. 1982;1:175–176[CrossRef][Medline]
11. Solis-Herruzo JA, Moreno D, Gonzalez A, et al. Effect of intrathoracic pressure on plasma arginine vasopressin levels. Gastroenterology. 1991;101:607–617[Medline]
12. Aho M, Lehtinen A-M, Laatikainen T, Korttila K. Effects of intramuscular clonidine on hemodynamic and plasma ß-endorphin responses to gynecologic laparoscopy. Anesthesiology. 1990;72:797–802[Medline]
13. Aho M, Scheinin M, Lehtinen AM, Erkola O, Vuorinen J, Korttila K. Intramuscularly administered dexmedetomidine attenuates hemodynamic and stress hormone responses to gynecologic laparoscopy. Anesth Analg. 1992;75:932–939[Abstract/Free Full Text]
14. Veith RC, Best JD, Halter JB. Dose-dependent suppression of norepinephrine appearance rate in plasma by clonidine in man. J Clin Endocrinol Metab. 1984;59:151–155[Abstract]
15. Reid IA, Ahn JN, Trinh T, Shackelford R, Weintraub M, Keil LC. Mechanism of suppression of vasopressin and adrenocorticotropic hormone secretion by clonidine in anesthetized dogs. J Pharmacol Exp Ther. 1984;229:1–8[Abstract/Free Full Text]
16. Weicker H, Ferandi M, Hägele H, Pluto R. Electrochemical detection of catecholamines in urine and plasma after separation with HPLC. Clin Chim Acta. 1984;141:17–25[CrossRef][Medline]
17. Legros JJ, Ansseau M. Vasopressin-neurophysin and bipolar depression: a case report. Biol Psychiatry. 1986;21:1212–1216[CrossRef][Medline]
18. Takata M, Wise RA, Robotham JL. Effects of abdominal pressure on venous return: abdominal vascular conditions. J Appl Physiol. 1990;69:1961–1972[Abstract/Free Full Text]
19. Kashtan J, Green JF, Parsons EQ, Holcroft JW. Hemodynamic effects of increased abdominal pressure. J Surg Res. 1981;30:249–255[CrossRef][Medline]
20. Goodale RL, Beebe DS, McNevin MP, et al. Hemodynamic, respiratory, and metabolic effects of laparoscopic cholecystectomy. Am J Surg. 1993;166:533–537[CrossRef][Medline]
21. Dorsay DA, Greene FL, Baysinger CL. Hemodynamic changes during laparoscopic cholecystectomy monitored with transesophageal echocardiography. Surg Endosc. 1995;9:128–134[Medline]
22. McLaughlin JG, Scheeres DE, Dean RJ, Bonnell BW. The adverse hemodynamic effects of laparoscopic cholecystectomy. Surg Endosc. 1995;9:121–124[Medline]
23. Westerband A, Van de Water JM, Amzallag M, et al. Cardiovascular changes during laparoscopic cholecystectomy. Surg Gynecol Obstet. 1992;175:535–538[Medline]
24. Odeberg S, Ljungqvist O, Svenberg T, et al. Haemodynamic effects of pneumoperitoneum and the influence of posture during anaesthesia for laparoscopic surgery. Acta Anaesthesiol Scand. 1994;38:276–283[Medline]
25. Cunningham AJ, Turner J, Rosenbaum S, Rafferty T. Transoesophageal echocardiographic assessment of haemodynamic function during laparoscopic cholecystectomy. Br J Anaesth. 1993;70:621–625[Abstract/Free Full Text]
26. Harris SN, Ballantyne GH, Luther MA, Perrino AC. Alterations of cardiovascular performance during laparoscopic colectomy: a combined hemodynamic and echocardiographic analysis. Anesth Analg. 1996;83:482–487[Abstract]
27. Melville RJ, Forsling ML, Frizis HI, LeQuesne LP. Stimulus for vasopressin release during elective intra-abdominal operations. Br J Surg. 1985;72:979–982[Medline]
28. Longhurst JC, Spilker HL, Ordway GA. Cardiovascular reflexes elicited by passive gastric distension in anesthetized cats. Am J Physiol. 1981;240:H539–H545
29. Montani J-P, Liard J-F, Schoun J, Möhring J. Hemodynamic effects of exogenous and endogenous vasopressin at low plasma concentrations in conscious dogs. Circ Res. 1980;47:346–355[Abstract/Free Full Text]
30. Kopp UC, DiBona GF. Interaction between neural and non-neural mechanisms controlling renin secretion rate. Am J Physiol. 1984;246:F620–F626
31. Kubota K, Kajira N, Teruya M, et al. Alterations in respiratory function and hemodynamics during laparoscopic cholecystectomy under pneumoperitoneum. Surg Endosc. 1993;7:500–504[CrossRef][Medline]
32. Iwase K, Takenaka H, Ishizaka T, Ohata T, Oshima S, Sakaguchi K. Serial changes in renal function during laparoscopic cholecystectomy. Eur Surg Res. 1993;25:203–212[Medline]
33. Flacke JW, Bloor BC, Flacke WE, et al. Reduced narcotic requirement by clonidine with improved hemodynamic and adrenergic stability in patients undergoing coronary bypass surgery. Anesthesiology. 1987;67:11–19[CrossRef][Medline]
34. Engelman E, Lipszyc M, Gilbart E, et al. Effects of clonidine on anesthetic drug requirements and hemodynamic response during aortic surgery. Anesthesiology. 1989;71:178–187[CrossRef][Medline]
35. Maze M, Tranquilli W. Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology. 1991;74:581–605[Medline]
36. Muzi M, Goff DR, Kampine JP, Roerig DL, Ebert TJ. Clonidine reduces sympathetic activity but maintains baroreflex responses in normotensive humans. Anesthesiology. 1992;77:864–871[CrossRef][Medline]
37. Lanes R, Herrera A, Palacios A, Moncada G. Decreased secretion of cortisol and ACTH after oral clonidine administration in normal adults. Metabolism. 1983;32:568–570[CrossRef][Medline]
38. Slowinska-Srzednicka J, Zgliczynski S, Soszynski P, Pucilowska J, Wierzbicki M, Jeske W. Effect of clonidine on beta-endorphin, ACTH and cortisol secretion in essential hypertension and obesity. Eur J Clin Pharmacol. 1988;35:115–121[CrossRef][Medline]
39. Baranowska B. The effect of clonidine on pituitary hormone secretion in physiological and pathological states. J Cardiovasc Pharmacol. 1987;12:S235–S239[CrossRef]
40. Guthrie GP, Kotchen TA, Van Loon GR. Effect of transdermal clonidine on the endocrine responses to insulin-induced hypoglycemia in essential hypertension. Clin Pharmacol Ther. 1989;45:417–423[Medline]
41. Milsom SR, Donald RA, Espiner EA, Nicholls MG, Livesey JH. The effect of peripheral catecholamine concentrations on the pituitary-adrenal response to corticotrophin releasing factor in man. Clin Endocrinol. 1986;25:241–246[Medline]
42. Pouttu J, Scheinin H, Rosenberg P, Viinamäki O, Scheinin M. Oral premedication with clonidine: effects on stress responses during general anesthesia. Acta Anaesthesiol Scand. 1987;31:730–734[Medline]
43. Robertson GL, Athar S. The interaction of blood osmolality and blood volume in regulating plasma vasopressin in man. J Clin Endocrinol Metab. 1976;42:613–620[Abstract]
44. Ghignone M, Noe C, Calvillo O, Quintin L. Anesthesia for ophthalmic surgery in the elderly: effects of clonidine on intraocular pressure, perioperative hemodynamics, and anesthesia requirement. Anesthesiology. 1988;68:707–716[CrossRef][Medline]
45. Ho HS, Saunders CJ, Corso FA, Wolfe BM. The effects of CO₂ pneumoperitoneum on hemodynamics in hemorrhaged animals. Surgery. 1993;114:381–388[Medline]
46. Safran D, Sgambati S, Orlando R III. Laparoscopy in high-risk cardiac patients. Surg Gynecol Obstet. 1993;176:548–554[Medline]

This article has been cited by other articles:

				P. Tauzin-Fin, M. Sesay, P. Gosse, and P. Ballanger Effects of perioperative {alpha}1 block on haemodynamic control during laparoscopic surgery for phaeochromocytoma Br. J. Anaesth., April 1, 2004; 92(4): 512 - 517. [Abstract] [Full Text] [PDF]

				J. L. Joris, N. J. Poth, A. M. Djamadar, D. I. Sessler, E. E. Hamoir, T. R. Defechereux, M. R. Meurisse, and M. L. Lamy Supplemental oxygen does not reduce postoperative nausea and vomiting after thyroidectomy{dagger} Br. J. Anaesth., December 1, 2003; 91(6): 857 - 861. [Abstract] [Full Text] [PDF]

				P. Lindstrom, J. Wadstrom, A. Ollerstam, C. Johnsson, and A. E. G. Persson Effects of increased intra-abdominal pressure and volume expansion on renal function in the rat Nephrol. Dial. Transplant., November 1, 2003; 18(11): 2269 - 2277. [Abstract] [Full Text] [PDF]

				H. A. Mowafi, A. Al-Ghamdi, and A. Rushood Intraocular Pressure Changes During Laparoscopy in Patients Anesthetized with Propofol Total Intravenous Anesthesia Versus Isoflurane Inhaled Anesthesia Anesth. Analg., August 1, 2003; 97(2): 471 - 474. [Abstract] [Full Text] [PDF]

				E. Huettemann, C. Terborg, S. G. Sakka, G. Petrat, F. Schier, and K. Reinhart Preserved CO2 Reactivity and Increase in Middle Cerebral Arterial Blood Flow Velocity During Laparoscopic Surgery in Children Anesth. Analg., February 1, 2002; 94(2): 255 - 258. [Abstract] [Full Text] [PDF]

				F. Decailliot, D. Cherqui, B. Leroux, M. Lanteri-Minet, S. B. Said, E. Husson, P. Duvaldestin, and F. Stephan Effects of portal triad clamping on haemodynamic conditions during laparoscopic liver resection Br. J. Anaesth., September 1, 2001; 87(3): 493 - 496. [Abstract] [Full Text] [PDF]

				C. Lentschener, D. Benhamou, C. Mann, and P. Colson Is Laparoscopic Surgery Associated with Specific Hemodynamic Changes? • Response Anesth. Analg., March 1, 2000; 90(3): 769 - 770. [Full Text] [PDF]

				J. L. Joris, E. E. Hamoir, G. M. Hartstein, M. R. Meurisse, B. M. Hubert, C. J. Charlier, and M. L. Lamy Hemodynamic Changes and Catecholamine Release During Laparoscopic Adrenalectomy for Pheochromocytoma Anesth. Analg., January 1, 1999; 88(1): 16 - 21. [Abstract] [Full Text] [PDF]

This Article Abstract Figures Only Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Joris, J. L. Articles by Lamy, M. L. Search for Related Content PubMed PubMed Citation Articles by Joris, J. L. Articles by Lamy, M. L.