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Figure 1 Study schema of the PROVED and RADIANCE studies. Following a period of single-blind stabilization, patients were randomized to continue or discontinue digoxin while maintaining background therapy as indicated. Treatment failure was determined by a committee blinded to drug assignment. ACEI = angiotensin-converting enzyme inhibitor, Chg Dig = investigator change in digoxin dose, CXR = chest x-ray, Echo = echocardiogram, ER = emergency room, ETT = maximal treadmill exercise test, HF = heart failure, Hx = history, LVEF = left ventricular ejection fraction, NYHA = New York Heart Association functional class, PE = physical examination, SDC = serum digoxin concentration, Wk = week, 6 MinWalk = 6 min walk test.
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